British Air Force Typhoon FGR4s have joined forces with France's air force in a coordinated attack targeting an underground arms cache in Syrian territory used by the IS group, according to the UK's MoD.
The site, located using reconnaissance, was believed to be containing munitions and bombs, the statement said, and was positioned in mountainous terrain just north of Palmyra in central Syria.
"The RAF jets employed Paveway IV guided bombs to target a several entry passages leading to the facility... initial indications indicate the target was engaged successfully," the ministry announced.
There was no evidence of any civilian impact in the operation late on Saturday and every plane involved returned safely, the ministry further stated.
The Typhoon fighters were assisted by a Voyager tanker plane.
Daesh - also known as Daesh - established jihadist rule over parts of both Syria and Iraq before its territorial defeat in 2019.
"This action shows our UK leadership, and resolve to work closely with our allies, to eliminate any resurgence of Daesh and their dangerous and violent ideologies in the area," Britain's Defence Chief the minister said.
UK warplanes have performed overwatch operations over Syrian airspace to "prevent any attempted resurgence" of Islamic State subsequent to its defeat at the battle of Baghuz in 2019, the authorities noted.
"I want to thank the personnel of our armed forces participating in this strike for their expertise and their courage," he added. "Including them were a great many British troops on duty over the holidays. This action, to eliminate dangerous terrorists who pose a risk to our security, demonstrates how British military are always on standby, throughout the year, protecting the UK at home and powerful internationally."
Last December, the American forces carried out what it called a "large-scale strike" targeting Islamic State objectives in Syria, after an attack claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The U.N. estimates IS still boasts an estimated 5,000 to 7,000 militants in both countries.